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Ovidrel- reliable in terms of ovulating 36-40 hours after?

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Bibliophile Posted: Sun, Oct 9 2011 7:49 AM

Does anyone have experience/knowledge of ovulating early after triggering with Ovidrel?

We finally got to try an IUI this time, after my first two cycles produced two big follicles on my right side (where I have a blocked tube).  This time I had two on the right again (each 17mm), but also a 19mm on the left.  The RE predicted that all three would release.

I gave myself the Ovidrel injection that night (Thursday) around 8 p.m.  The RE said I should ovulate 36-40 hours later.

The next day, on Friday afternoon, I felt a sharp, brief pain in my left ovary.  I was concerned that it might be an ovluation pain, but I've had so many twinges and discomforts that I didn't worry too much.  But the next morning, the morning of my IUI, my temperature had already jumped.  It's true that I didn't sleep very well the night before the IUI, since I was anxious about oversleeping. So it's possible that could have caused my temp to be higher.

My cervix was still very soft and open, which reassured me a little bit.

During the IUI I asked the doctor if it was possible that I had ovulated the day before, and he said that Ovidrel is very dependable in causing ovulation 36-40 hours after trigger- so he didn't believe it was possible that I had. 

Still- could he be wrong? I hate to think that we did this for nothing.

Me: 35 DH: 37
Baby Boy: 4 yrs old, drug-free hospital birth w/ midwife (TTC 3 mos)
Baby Boy: born June 2012, labor ending with C-section due to fetal distress (TTC 26 mos)



September 2009: started TTC #2
August 2010:  diagnosed with Hashimoto's; Right tube blocked; diminished ovarian reserve (DOR)
September 2010 - August 2011:  various doses of Levoxyl, fertility acupuncture & Chinese herbs
August 2011: Clomid 50mg + trigger + IUI.  (IUI cancelled- 2 follies on side of blocked tube)
September 2011: Clomid 50mg + trigger + IUI.  (cancelled- 2 follies on side of blocked tube again)
October 2011: 3rd time's a charm? Clomid 50mg + trigger + IUI (two follies on right, but also a big one on the left this time!)
                           Holy cow- BFP!  Beta = 323 17dpiui, 716 19dpiui, and 2,651 23dpiui

                          

my chart

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Posts 797
rebeccas replied on Sun, Oct 9 2011 8:27 AM

Hi there - I did an IUI cycle in August and I think I had a similar situation. It is hard to be sure if you weren't doing OPKs and didn't sleep well that night, but it *is* possible in my opinion. I think I ovulated 24 hours after trigger, and missed my window for the IUI. So, this cycle, I have requested my IUI to be scheduled 24 hours after trigger, because too early is better than too late. I will also have sex the night before the trigger, the day of the trigger and the day after the IUI, just to be safe.

 

Good luck!


Cycle 1-3 here: http://tcoyf.com/members/rebeccas/pccharts/3.aspx

Current charts: http://tcoyf.com/members/rebeccas/charts/default.aspx

Rebecca: 32 years oldBig Smile DH: 34 years oldLaugh

TTC #1 since Jan. 2010 after 15 years on BCP. One Angel, and PCOS.

Lots of unmedicated cycles, 2 Clomid cycles, 2 Gonal-F/Ovidrel/IUI cycles = BFN. Onto IVF in 2012.
January 2012 - 23 eggs retrieved, 19 mature, none fertilize.

April 2012: IVF#2: with ICSI. 26 retrieved, 20 fert, 5dt, BFP! Chick 6 in the freezer.

The Nugget is due New Year's Day, 2013! Baby Boy

A perfect Christmas gift: Max David arrived 12/25/12!Baby Boy

Full timeline in my bio Smile

My blog: http://waitingforlittlefeet.blogspot.com/

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Bibliophile replied on Sun, Oct 9 2011 8:54 AM

Thanks, Rebecca. I use the Clearblue Easy fertility monitor and I got peak fertility the morning after I triggered- but I figured that was natural since I had given myself the shot.  We did have sex the night of the trigger, but not the day after, per the RE's instructions. Ugh.

Me: 35 DH: 37
Baby Boy: 4 yrs old, drug-free hospital birth w/ midwife (TTC 3 mos)
Baby Boy: born June 2012, labor ending with C-section due to fetal distress (TTC 26 mos)



September 2009: started TTC #2
August 2010:  diagnosed with Hashimoto's; Right tube blocked; diminished ovarian reserve (DOR)
September 2010 - August 2011:  various doses of Levoxyl, fertility acupuncture & Chinese herbs
August 2011: Clomid 50mg + trigger + IUI.  (IUI cancelled- 2 follies on side of blocked tube)
September 2011: Clomid 50mg + trigger + IUI.  (cancelled- 2 follies on side of blocked tube again)
October 2011: 3rd time's a charm? Clomid 50mg + trigger + IUI (two follies on right, but also a big one on the left this time!)
                           Holy cow- BFP!  Beta = 323 17dpiui, 716 19dpiui, and 2,651 23dpiui

                          

my chart

Top 500 Contributor
Posts 797
rebeccas replied on Sun, Oct 9 2011 9:12 AM

If you had sex the night of the trigger then I wouldn't worry!! You had good timing! I am crossing my fingers for you.


Cycle 1-3 here: http://tcoyf.com/members/rebeccas/pccharts/3.aspx

Current charts: http://tcoyf.com/members/rebeccas/charts/default.aspx

Rebecca: 32 years oldBig Smile DH: 34 years oldLaugh

TTC #1 since Jan. 2010 after 15 years on BCP. One Angel, and PCOS.

Lots of unmedicated cycles, 2 Clomid cycles, 2 Gonal-F/Ovidrel/IUI cycles = BFN. Onto IVF in 2012.
January 2012 - 23 eggs retrieved, 19 mature, none fertilize.

April 2012: IVF#2: with ICSI. 26 retrieved, 20 fert, 5dt, BFP! Chick 6 in the freezer.

The Nugget is due New Year's Day, 2013! Baby Boy

A perfect Christmas gift: Max David arrived 12/25/12!Baby Boy

Full timeline in my bio Smile

My blog: http://waitingforlittlefeet.blogspot.com/

Top 500 Contributor
Posts 675
Sammy1 replied on Sun, Oct 9 2011 5:19 PM

Hi there, I just want to chime in and tell you what my RE said. He said (almost) the same thing as yours: The Ovidrel is extremely reliable about timing O; O will happen 36-44 (not 36-40 like yours said) hours after Ovidrel injection. He told me the action of Ovidrel is extremely predictable and there's very little variation.

I think if you O'd earlier it would be because your body was ready to O and they mistimed the trigger/IUI and not because the Ovidrel caused you to O less than 36 hours later. I personally think it's very probable your temp jumped because you didn't sleep well. And like a pp said, you BD'd on trigger night so if the IUI was mistimed (which I think there's a good chance it wasn't) all may not be lost.

I wish you the best of luck!! Flowers

Me (35) + DH (39) + 4 furbabies = Heart

TTC #1 since October 2010, see my bio for infertility history

July 19, 2012: FET #1 of the one blast frozen from first fresh IVF-- BFP at 5dp5dt!! Baby   beta #1, 6dp5dt = 20; beta #2, 12dp5dt = 412 (DT = 34 hours); beta #3, 14 dp5dt = 907 (DT = 42 hours). EDD April 6, 2013. It's a Baby Boy!

April 19, 2013: Baby Boy born 41w6d at 9lbs6oz!

 

My Chart               

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Posts 1,050
chrissybits replied on Sun, Oct 9 2011 7:03 PM

Bibliophile:
We finally got to try an IUI this time, after my first two cycles produced two big follicles on my right side (where I have a blocked tube).  This time I had two on the right again (each 17mm), but also a 19mm on the left.

So glad to hear you were able to get a follie on the left this time! I used Ovidrel for my two IUIs and Novarel for my IVF (not sure what the difference is, I think they are both HCG). I didn't think about the timing very much for the IUIs but I was very worried I would ovulate early for the IVF when I showed up for the egg retrieval. They timed it exactly 36 hours after my trigger and they even had me wait an extra day before the trigger to give the small ones a chance to catch up. All 5 ended up maturing and were ready to be retrieved. So I would say their insistence on the 36 hour timeframe shows that they are confident in the trigger causing ovulation in that time.

Good luck! Baby Dust 

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Posts 309
Bibliophile replied on Sun, Oct 9 2011 9:51 PM

Thanks, all! I appreciate the encouragement. Sammy- it's entirely possible that the RE said "36-44 hours" and I just misunderstood.  I was a little preoccupied, what with the speculum and the catheter and whatnot. Wink

Me: 35 DH: 37
Baby Boy: 4 yrs old, drug-free hospital birth w/ midwife (TTC 3 mos)
Baby Boy: born June 2012, labor ending with C-section due to fetal distress (TTC 26 mos)



September 2009: started TTC #2
August 2010:  diagnosed with Hashimoto's; Right tube blocked; diminished ovarian reserve (DOR)
September 2010 - August 2011:  various doses of Levoxyl, fertility acupuncture & Chinese herbs
August 2011: Clomid 50mg + trigger + IUI.  (IUI cancelled- 2 follies on side of blocked tube)
September 2011: Clomid 50mg + trigger + IUI.  (cancelled- 2 follies on side of blocked tube again)
October 2011: 3rd time's a charm? Clomid 50mg + trigger + IUI (two follies on right, but also a big one on the left this time!)
                           Holy cow- BFP!  Beta = 323 17dpiui, 716 19dpiui, and 2,651 23dpiui

                          

my chart

Not Ranked
Posts 165
earlyspring replied on Tue, Oct 11 2011 12:32 PM

I had the opposite issue last cycle, my temp didn't spike until 3 days after the IUI (four days after the trigger shot). This cycle I brought up my concerns to my RE that maybe we did the IUI too early and she said the same thing as your doc, that Ovidrel has been very closely studied and that it consistently triggers O 36-44 hours after the shot. So in my case it seemed like maybe my temps were just slow to rise. In yours, hopefully it was the poor sleep. GL!

DH (30)  Heart Me (30) 

Almost two years= 2 miscarriages, one laparoscopy and BabyBaby twins due 12/20/12 through IUI 

 BabyFruit Ticker

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Posts 85
kittymommy replied on Tue, Oct 11 2011 1:07 PM

Hi there, I just wanted to chime in.  I did an IUI cycle with Femara and Gonal F back in August and we did our Ovidrel trigger 36 hours before IUI.  We also BD the evening of the trigger & evening of IUI.  I ended up getting PG from that cycle with twins (actually was a triplet pregnancy but third sac was measuring way behind).  Unfortunately we lost both about 10 days ago at 8 weeks - heartbeats had stopped and development was a little behind.  I agree that the Ovidrel is usually very predictable at pinpointing O 36-40 hrs after but it's also good to BD on your own just to cover your bases.

Me (36), DH (37)

September 2010 - Myomectomy, DH varicocele surgery

#1 IUI - August 2011 (Femara + Gonal-F + acupuncture) = BFP Angel twins at 8.5 weeks | 9 DPO BFP, 14 DPO Beta = 392, 16 DPO Beta = 963

Chemical October 2011

#2 IUI - December 2011 (Femara + Gonal-F + acupuncture) = BFP Angel at 8 weeks | 18 DPO = 214, 20 DPO = 381, 23 DPO = 1058, 25 DPO = 2252 | 1/27/12 heartbeat! 2/3/12 ultrasound shows slower HB and measuring 2 weeks behind. 2/17/12 D&C.  4/5/2012 2nd D&C and hysteroscopy. 

IVF #1 Transferred 2 CGH normal 6-day blasts 5/4/12.  Chemical

FET July 20, 2012 - Transferred one CGH normal 6 day blast.  BFP 4 dpt!  7/30 Beta #1 = 100, 8/1 Beta #2 = 217.  Currently under care of reproductive immunology specialist and taking Lovenox & Neupogen in addition to FET meds to support this pregnancy. 

Baby Girl late March 2013

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Posts 309
Bibliophile replied on Tue, Oct 11 2011 7:22 PM

Thank you, Tullyar and Kittymommy- this helps me have more confidence in the Ovidrel. We did have sex the night of the trigger, and the afternoon of the IUI, so I hope we had plenty of swimmers to catch that one little egg. And Kittymommy, I'm so sorry about the loss of your triplets. I wish you the best of luck with whatever you choose to do next.  Flowers

Me: 35 DH: 37
Baby Boy: 4 yrs old, drug-free hospital birth w/ midwife (TTC 3 mos)
Baby Boy: born June 2012, labor ending with C-section due to fetal distress (TTC 26 mos)



September 2009: started TTC #2
August 2010:  diagnosed with Hashimoto's; Right tube blocked; diminished ovarian reserve (DOR)
September 2010 - August 2011:  various doses of Levoxyl, fertility acupuncture & Chinese herbs
August 2011: Clomid 50mg + trigger + IUI.  (IUI cancelled- 2 follies on side of blocked tube)
September 2011: Clomid 50mg + trigger + IUI.  (cancelled- 2 follies on side of blocked tube again)
October 2011: 3rd time's a charm? Clomid 50mg + trigger + IUI (two follies on right, but also a big one on the left this time!)
                           Holy cow- BFP!  Beta = 323 17dpiui, 716 19dpiui, and 2,651 23dpiui

                          

my chart

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